Prognostic value of the right ventricle diameter, pulmonary arterial pressure and biomarkers in patients with acute heart failure

By

Dejan Petrović ,

Dejan Petrović

View authors publications

Search this author on:

PubMed | Google Scholar

Marina Deljanin-Ilić ,

Marina Deljanin-Ilić

View authors publications

Search this author on:

PubMed | Google Scholar

Sanja Stojanović ,

Sanja Stojanović

View authors publications

Search this author on:

PubMed | Google Scholar

Dejan Simonović ,

Dejan Simonović

View authors publications

Search this author on:

PubMed | Google Scholar

Dijana Stojanović ,

Dijana Stojanović

View authors publications

Search this author on:

PubMed | Google Scholar

Valentina Mitić ,

Valentina Mitić

View authors publications

Search this author on:

PubMed | Google Scholar

Milovan Stojanović

Milovan Stojanović

View authors publications

Search this author on:

PubMed | Google Scholar

Abstract

The aim of the paper was to examine the echocardiographic parameters of the right ventricle (RV), its diameter and pulmonary arterial pressure (PAP); to determine their relationship to B-type natriuretic peptide (BNP), troponin and (TnI) and high-sensititity C-raective protein (hsCRP), and to evaluate their prognostic significance to one-year mortality in patients with acute heart failure (AHF). The study included a total of 225 patients (pts) (70.29 ± 9.74 years) who were admitted to Intensive care unit due to the signs and symptoms of AHF. The values of standard biochemical parameters, BNP, TnI and hsCRP were determined during the first 24 hours after admission. All patients underwent echocardiographic examination. During a one-year follow-up, 78 (34.70%) patients died. As compared with the group of survivors (n = 147), the group of non-survivors had higher values of BNP (853.10 ± 384.92 vs. 1399.68 ± 464.44 pg/mL, p < 0.001), TnI (0.59 ± 2.04 vs. 2.00 ± 8.29 ng/ml, p < 0.05), right ventricular diameter and PAP (p < 0.001). BNP was positively correlated with TnI (r = 0.311), PAP (r = 0.255) and right ventricular diameter (r = 0.304, p < 0.001 for all correlations). The cut-off value of BNP ≥ 1062.04 pg/ml, PAP ≥ 44.5 mmHg and TnI ≥ 0.04 ng/ml were associated with a higher risk of mortality. Our results have shown that BNP, PAP and TnI are strong and independent predictors of one-year mortality in hospitalized patients with acute heart failure.

References

Citation

Copyright

Article metrics