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Research paper
Published: 01.12.2015.
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https://doi.org/10.1515/afmnai-2016-0017

Resistance in Staphylococcus Aureus: The Never-Ending Story

By
Jovan Orlović ,
Jovan Orlović
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Biljana Miljković-Selimović ,
Biljana Miljković-Selimović
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Marina Dinić ,
Marina Dinić
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Ljiljana Ristić
Ljiljana Ristić
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Abstract

SummaryCombating Staphylococcus aureus (S. aureus) infections using antibacterial drugs is actually an ongoing effort to overcome resistance mechanism of this microorganism. In this paper, we discussed (1) the mechanisms of resistance to some of the most commonly used antimicrobial agents in the treatment of S. aureus: methicillin, vancomicyn and quinolones. In addition, (2) efflux pump mechanisms involved in maintaining homeostasis in the presence of compounds that inhibit S. aureus growth and reproduction, as well as mechanisms of resistance to a number of antibiotics, have been reviewed.

References

1.
The structure of β-lactamases. Philosophical Transactions of the Royal Society of London B, Biological Sciences. 1980;289(1036):321–31.

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