Sarcoidosis is characterized by granulomatous inflammation developing in the affected organs. The ethiopathogenesis of the disease is still unknown. The lungs are most commonly affected, and uncontrolled, long-lasting inflammation can result in pulmonary fibrosis. Many different mediators, such as cytokines, chemokines, and other proteins with vari...

By Tatjana Rađenović Petković, Tatjana Pejčić, Desa Nastasijević Borovac, Danijela Radojković, Sonja Cekić

A 64-year-old patient with extremely high number of white blood cells was diagnosed with T prolymphocytic leukemia. After the initiation of chemotherapy with Cyclophosphamide, Oncovin, Doxorubicin and Prednisone (CHOP), there was no improvement and the patient died within two months. Authors have made a review of the current therapy of this rare di...

By Goran Marjanović, Vesna Nikolić, Tomislav Vukićević, Lana Mačukanović Golubović, Dragana Drašković

Starting from reduced definition of health in terms of absence of disease and invalidity, the paper explains the applicability of three cardinal principles of economics (scarcity of resources and imperative of choice, opportunity costs, marginal analysis) on extremely sensitive area of economic evaluation of health care. An attempt was made to reco...

By Slobodan Cvetanović

Community-acquired pneumonia (CAP) is the most common cause of death among infectious diseases.During the management of pneumonia, it is often uncertain when the disease may turn into severe form. The first definition of severe CAP was provided by the ATS Guidelines. Definition was built up around simple clinical and radiographic criteria reflectin...

By Desa Nastasijević Borovac, Tatjana Pejčić, Tatjana Rađenović Petković, Vidosava Đorđević, Ivanka Đorđević, Ivana Stanković, Milan Rančić

Muscle fiber types and  their metabolic and size properties, key determinants of muscle function, can be altered by variety of factors. The aim of this study was to evaluate and compare the fiber type composition and size of fibers in the tibialis anterior (TA) muscle of young adult male and female rats, using histochemical and morphometric me...

By Desanka Tasić, Irena Dimov, Vladimir Petrović, Todorka Savić, Dragan Dimov

In many physiological processes, peptides play a critical role as neurotransmitters, hormones, antibiotics, etc. They have research importance in fields such as immunology, pharmacology, neuroscience and cell biology. There are many approaches for immunotherapies: some of them use the peptides as important components of chimeric molecules for immun...

By Stefan Dačić, Dragica Simonović Dačić, Goran Radičević, Aleksandar Mitić, Goran Tošić, Ivan Ristić, Stefan Veličković

Obsessive-compulsive disorder (OCD) is defined by the presence of either obsession or compulsion that is severe enough to be time consuming or to cause marked distress or significant impairment. At some point during the course of the disorder, the person recognizes that the obsessions and compulsions are excessive or unreasonable. Twenty-one p...

By Lydia Sushevska, Nichola Olumchev, Mirjana Saveska

Perforation of peptic ulcer (PPU) is the most frequent complication of peptic ulcer disease. PPU is a serious complication which demands urgent diagnostic procedures, reanimation and surgical intervention.  The aim of this study was to establish the frequency of PPU, diagnostic and therapy procedures, time and kind of surgical methods, as well...

By Ivana Đorđević, Aleksandar Zlatić, Irena Janković

Abdominal aortic aneurysm (AAA) is a complex disease defined as a pathologic dilatation of the infrarenal aorta that is often accompanied by significant superimposed atherosclerosis, inflammation and thrombosis. AAAs are a significant cause of morbidity and mortality in the United States and worldwide. While some patients may present with lower bac...

By Philip Tsao, Ivana Burazor

Surgical treatment of the patients with gynecologic diseases is warranted only when all the conservative treatment approaches have been exhausted. Surgical treatment is a stress for the patient, and associated risks and complications may be life-threatening. Surgery may be performed after the patient has been informed and her written consent obtain...

By Goran Lilić, Radomir Živadinović, Aleksandra Petrić, Vekoslav Lilić