The role of serum vitamin D concentrations in predicting COVID-19 course and outcome

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Dunja Božić ,

Dunja Božić

Clinical Centre of Kragujevac , Kragujevac , Serbia

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Đorđe Stevanović ,

Đorđe Stevanović

Clinical Centre of Kragujevac , Kragujevac , Serbia

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Mina Poskurica ,

Mina Poskurica

Clinical Centre of Kragujevac , Kragujevac , Serbia

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Marina Petrović

Marina Petrović

Clinical Centre of Kragujevac , Kragujevac , Serbia

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Abstract

Introduction/Aim. The coronavirus disease 2019 (COVID-19) pandemic had significant acute and long-term impact on people's health. As the available literature sources have shown that the premorbid conditions affect the course of COVID-19, we aimed to investigate the role of admission vitamin D concentration to predict the outcome of hospitalized COVID-19 patients. Methods. An observational, prospective cohort study was conducted on 329 COVID-19 patients hospitalized at the University Clinical Centre Kragujevac, between October and December 2021. Within 24 hours of admission, vitamin D level was measured from the peripheral venous blood. Medical history data and socio-demographic characteristics were obtained anamnestically and using Health Information System (COMTRADE, Serbia). Lethal outcome and intensive care unit (ICU) admission were considered primary end-points. Results. The prevalence of hypovitaminosis D on admission in our cohort was 27.7%. Both non-survivors and patients requiring ICU admission more frequently had hypovitaminosis D compared to survivors (42,9% versus 21,0%; p < 0,001) and patients on a standard level of care (31,5% verus 25,3%; p = 0,029). Our research showed that vitamin D concentration < 20 ng/mL was an independent predictor of mortality (aOR 2.142 [95% CI 1.226 - 3.744]). However, hypovitaminosis D upon hospital admission did not show a significant impact on ICU admission. Conclusion. Low vitamin D concentration on admission could be a significant predictor of outcome in hospitalized COVID-19 patients.

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