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Research paper
Published: 01.12.2021.
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https://doi.org/10.5937/afmnai39-34181

CCL2/MCP-1 serum chemokine level in patients with odontogenic infectious and inflammatory diseases of the soft tissues of the maxillofacial area and mediastinum

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Mariia Faustova ,
Mariia Faustova
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Oleksandr Nazarchuk ,
Oleksandr Nazarchuk
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Dmytro Dmytriiev ,
Dmytro Dmytriiev
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David Avetikov ,
David Avetikov
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Galina Loban ,
Galina Loban
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Yuliana Babina ,
Yuliana Babina
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Maiia Ananieva
Maiia Ananieva
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Abstract

Aim. The paper was aimed at determining the CCL2/MCP-1 level in patients with odontogenic infectious and inflammatory diseases of soft tissues of the maxillofacial area and mediastinum. Methods. The study involved 46 patients with odontogenic infectious and inflammatory diseases of soft tissues of the maxillofacial area and 12 healthy volunteers. The level of patients' plasma CCL2/MCP-1 level was determined using a kit for specific ELISA. Results. The findings of the studies showed a statistically significant increase in the concentration of plasma CCL2/MCP-1 in patients of all study groups. Our study shows a significant increase in plasma CCL2/MCP-1 level in patients with odontogenic phlegmonas, abscesses and mediastinitis, compared to the group of healthy subjects. Conclusion. CCL2/MCP-1 may play an important role in the pathogenesis of odontogenic infectious and inflammatory diseases of soft tissues of the maxillofacial area and mediastinum, which requires a careful follow-up study.

References

1.
Helsinki D. World Medical Association.

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